3-溴-4H-噻吩并[3,2-b]吡咯-5-羧酸乙酯合成路线 (共 3 条)
反应条件
1: sodium ethanolate / ethanol / 2.5 h / -10 - 20 °C 2: anhydrous xylene / 2 h / 120 °C View Scheme
参考文献
Hirayama, Takaharu; Okaniwa, Masanori; Imada, Takashi; Ohashi, Akihiro; Ohori, Momoko; Iwai, Kenichi; Mori, Kouji; Kawamoto, Tomohiro; Yokota, Akihiro; Tanaka, Toshimasa; Ishikawa, Tomoyasu
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5488 - 5502
反应条件
1: With potassium hydroxide; water in methanol T=85°C; 3 h; 2: With hydrogenchloride in methanol; water
参考文献
MERCK SHARP and DOHME LIMITED; MERCK and CO., INC.
Patent: WO2007/39773 A1, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
copper(l) chloride in N,N-dimethyl-formamide T=140°C; 16 h;
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 42 ;