3',5'-二氯-2'-羟基苯乙酮合成路线 （共 15 条）
反应条件
nitric acid in acetic acid
T=100°C; 0.5 h; other solvent: propionic acid; MechanismProduct distribution;
参考文献
Benedikt, George M.; Traynor, Lee
Tetrahedron Letters, 1987 , vol. 28, # 7 p. 763 - 766
反应条件
1: POCl3 / 12 h / 20 °C
2: Jones' reagent / acetone / 10 - 15 °C
View Scheme
参考文献
Galano, Juan J.; Alias, Miriam; Perez, Reyes; Velazquez-Campoy, Adrian; Hoffman, Paul S.; Sancho, Javier
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6248 - 6258
反应条件
1: potassium hydroxide / ethanol; water / 20 °C
2: iodine / dimethyl sulfoxide / |Reflux
View Scheme
参考文献
Sawant; Gill; Nirwan
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 297 - 300
反应条件
1: potassium hydroxide / ethanol; water / 20 °C
2: iodine / dimethyl sulfoxide / |Reflux
View Scheme
参考文献
Sawant; Gill; Nirwan
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 297 - 300
反应条件
bromine in acetic acid
Bromination; 1 h; Heating;
参考文献
Cascaval, Alexandru; Wegner, Gerhard
Revue Roumaine de Chimie, 1992 , vol. 37, # 6 p. 723 - 728
