(2-甲氧基-3-吡啶基)(2-噻吩基)甲酮合成路线 （共 2 条）
反应条件
1: 2-methoxy-pyridine With [(tBu)NCH(iPr)(tBu)]3Al*3(LiCl) in tetrahydrofuran T=25°C; 3 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-30°C; 0.25 h; Inert atmosphere; 3: 2-thiophenoyl chloride With CuCN*2LiCl in tetrahydrofuran T=-30 - 25°C; Inert atmosphere; regioselective reaction;
参考文献
Wunderlich, Stefan H.; Knochel, Paul
Angewandte Chemie - International Edition, 2009 , vol. 48, # 8 p. 1501 - 1504
反应条件
sodium methylate in methanol; water
参考文献
Eisai Co., Ltd.
Patent: US6599917 B1, 2003 ;
