2-(4-硝基苯基)咪唑并[1,2-a]吡啶合成路线 （共 16 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; 4 h; Inert atmosphereSealed vessel;
参考文献
Marhadour, Sophie; Marchand, Pascal; Pagniez, Fabrice; Bazin, Marc-Antoine; Picot, Carine; Lozach, Olivier; Ruchaud, Sandrine; Antoine, Maud; Meijer, Laurent; Rachidi, Najma; Le Pape, Patrice
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 543 - 556
反应条件
1: in acetone 3 h; HeatingReflux; 2: With ammonia in ethanol; water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAMILTON, Bradford, S.; MACK, Juergen; REDEMANN, Norbert; SCHOELCH, Corinna
Patent: WO2011/48018 A1, 2011 ;
Location in patent: Page/Page column 41 ;
WO 2011/048018 A1
反应条件
copper(l) iodide; oxygen in N,N-dimethyl-formamide T=110°C; P=760.051 Torr; 36 h; Schlenk techniqueSealed tubeGreen chemistry;
参考文献
Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua
Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808
反应条件
copper(l) iodide in 1,4-dioxane T=100°C; 14 h;
参考文献
Pericherla, Kasiviswanadharaju; Kaswan, Pinku; Khedar, Poonam; Khungar, Bharti; Parang, Keykavous; Kumar, Anil
RSC Advances, 2013 , vol. 3, # 41 p. 18923 - 18930
反应条件
1: 2-aminopyridine-N-oxide With trifluoroacetic acid in dichloromethane 0.166667 h; 2: 4-nitro-phenylacetylene With dichloro(pyridine-2-carboxylato)gold(III) in dichloromethane T=40°C; 15 h; regioselective reaction;
参考文献
Talbot, Eric P. A.; Richardson, Melodie; McKenna, Jeffrey M.; Toste, F. Dean
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 687 - 691
反应条件
potassium fluoride in N,N-dimethyl-formamide T=20 - 130°C; 12.1667 h; Inert atmosphere; regioselective reaction;
参考文献
Liu, Guoping; Cong, Xuefeng; He, Jiaheng; Luo, Shunzhong; Wu, Di; Lan, Jingbo
Journal of Chemical Research, 2012 , vol. 36, # 12 p. 687 - 690
反应条件
sodium hydrogencarbonate in ethanol 4 h; Heating;
参考文献
Singh, Shiv P.; Naithani, Rajesh; Prakash
Journal of the Indian Chemical Society, 1998 , vol. 75, # 10-12 p. 770 - 772
反应条件
1: 70 percent / acetonitrile / 2 h / Heating 2: 62 percent / NaHCO3 / ethanol / 4 h / Heating View Scheme
参考文献
Khedar, Poonam; Pericherla, Kasiviswanadharaju; Kumar, Anil
Synlett, 2012 , vol. 23, # 18 p. 2609 - 2614,6
反应条件
1.1: ethanol / 18.5 h / 0 °C / Reflux 1.2: 12 h / Reflux 2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Sealed vessel View Scheme
参考文献
Marhadour, Sophie; Bazin, Marc-Antoine; Marchand, Pascal
Tetrahedron Letters, 2012 , vol. 53, # 3 p. 297 - 300
反应条件
potassium carbonate in acetonitrile 10 h; Inert atmosphereRefluxsolid phase reaction;
参考文献
Wang, Chao-Li; Sheng, Shou-Ri.; Chen, Hu; Liu, Xiao-Ling; Cai, Ming-Zhong
Journal of Chemical Research, 2008 , # 5 p. 289 - 291
