4-[(叔丁氧羰基氨基)甲基]苯甲酸合成路线 （共 22 条）
反应条件
triethylamine in water-l,4-dioxane; water
参考文献
Roczniki Chemii, , vol. 45, p. 655 - 656
反应条件
1: 25 percent / NaHCO3 / dimethylformamide 2: 66 percent / 4 N HCl / dioxane / 1 h View Scheme
参考文献
Tamura; Matsushita; Iwama; Harada; Kishimoto; Itoh
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1199 - 1212
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; 1,4-dioxane T=0 - 20°C; 16.25 h;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117549 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/117549 A1
反应条件
sodium borohydride; triethylamine in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US6403578 B1, 2002 ;
反应条件
1: 86 percent / LiAlH4 / dioxane; tetrahydrofuran 2: 79 percent / Dess-Martin periodane / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
反应条件
1: 4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane
0.0833333 h;
2: methanol in dichloromethane
T=20°C; 18 h; Product distribution / selectivity;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 206-207 ;
WO 2010/020556 A1
反应条件
in diethyl ether
0.5 h;
参考文献
Eli Lilly and Company; Wayne State University; University of Hawaii
Patent: US6680311 B1, 2004 ;
Location in patent: Page/Page column 151 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
Tamura; Matsushita; Iwama; Harada; Kishimoto; Itoh
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1199 - 1212
