4-[(叔丁氧羰基氨基)甲基]苯甲酸合成路线 （共 22 条）
反应条件
1: ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 22 h / 4 - 20 °C / Inert atmosphere
2: DMEG; triethylamine; trifluoroacetic acid / dichloromethane / 21 h / 4 - 50 °C / Inert atmosphere
View Scheme
参考文献
Buckley, Dennis L.; Van Molle, Inge; Gareiss, Peter C.; Tae, Hyun Seop; Michel, Julien; Noblin, Devin J.; Jorgensen, William L.; Ciulli, Alessio; Crews, Craig M.
Journal of the American Chemical Society, 2012 , vol. 134, # 10 p. 4465 - 4468
反应条件
1: 100 percent / oxalyl chloride; pyridine / toluene; dimethylformamide / 6 h / 20 °C
2: 58 percent / pyridine / 13 h / 20 °C
3: 99 percent / aq. HCl / methanol / 13 h / 20 °C
4: 51.6 percent / Et3N; AcOH; NaBH3CN / methanol / 6 h / 20 °C
View Scheme
参考文献
Nagaoka; Maeda; Kawai; Nakashima; Oikawa; Shimoke; Ikeuchi; Kuwajima; Uesato
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 697 - 708
