2-乙氧基-4-乙氧基羰基甲基-苯甲酸乙酯合成路线 （共 8 条）
反应条件
carbon monoxide; dichlorobis (1,2,5-triphenylphosphole)palladium in ethanol T=50°C; 6 - 15 h;
参考文献
Kalkote, Uttam R.; Gurjar, Mukund K.; Joshi, Shreerang V.; Kadam, Suresh M.; Naik, Sanjay J.
Patent: US2004/192955 A1, 2004 ;
Location in patent: Page 3 ;
反应条件
1: With triethylamine in toluene T=25 - 35°C; 1 - 2 h; Heating / reflux; 2: With water in toluene T=80 - 85°C; 0.25 - 0.5 h;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC
Patent: US2004/249188 A1, 2004 ;
Location in patent: Page 4; 5 ;
反应条件
1: K2CO3 / diethyl ether / 30 h / 150 °C 2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 4: HCl / Heating View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 3: HCl / Heating View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
hydrogenchloride Heating;
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: With sodium hydroxide; water in methanol T=10 - 15°C; 1 - 2 h; 2: With hydrogenchloride in water T=0 - 5°C; pH=3 - 4;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC
Patent: US2004/249188 A1, 2004 ;
Location in patent: Page 4; 5 ;
反应条件
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C 2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature 3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
