(4-氟-3-硝基苯基)氨基甲酸叔丁酯合成路线 （共 8 条）
反应条件
in tetrahydrofuran 48.5 h; RefluxInert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2011/237620 A1, 2011 ;
Location in patent: Page/Page column 30 ;
US 20110237620 A1
反应条件
1: 88 percent / KNO3; conc. H2SO4 / 20 °C 2: oxalyl chloride; DMF / CH2Cl2 / 20 °C 3: sodium azide / CH2Cl2; dimethylformamide / 20 °C 4: CH2Cl2; dimethylformamide / Heating View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 20 °C 2: sodium azide / CH2Cl2; dimethylformamide / 20 °C 3: CH2Cl2; dimethylformamide / Heating View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
1: sodium azide / CH2Cl2; dimethylformamide / 20 °C 2: CH2Cl2; dimethylformamide / Heating View Scheme
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
in dichloromethane; N,N-dimethyl-formamide Heating;
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
1: NaH / dimethylsulfoxide 2: NaOH / methanol / 80 °C View Scheme
参考文献
Altorfer, Michael; Ermert, Philipp; Faessler, Juerg; Farooq, Saleem; Hillesheim, Elke; Jeanguenat, Andre; Klumpp, Klaus; Maienfisch, Peter; Martin, Joseph A.; Merrett, John H.; Parkes, Kevin E.B.; Obrecht, Jean-Pierre; Pitterna, Thomas; Obrecht, Daniel
Chimia, 2003 , vol. 57, # 5 p. 262 - 269
反应条件
hydrogen; palladium in methanol T=20°C;
参考文献
Kuramoto, Yasuhiro; Ohshita, Yoshihiro; Yoshida, Jiro; Yazaki, Akira; Shiro, Motoo; Koike, Tohru
Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1905 - 1917
反应条件
1.1: sodium hydride / dimethyl sulfoxide / 15 - 20 °C 1.2: 48 h / 80 - 90 °C 2.1: sodium hydroxide; methanol / 20 °C 2.2: pH 3 3.1: hydrogen / palladium 10 on activated carbon / methanol / 20 °C 3.2: 3 h / Reflux 3.3: 20 °C / pH 5 View Scheme
参考文献
YUHAN CORPORATION; SIM, Jae-Young; CHA, Myung-Hun; KIM, Tae-Kyun; LEE, Hyun-Joo; YOON, Young-Ae; KIM, Dong-Hoon; AHN, Hee-Jeong; LEE, Tai-Au; AHN, Kyoung-Kyu; HYUN, Kwan-Hoon
Patent: WO2012/115479 A2, 2012 ;
