2-羟基-5-三氟甲基吡啶合成路线 （共 18 条）
反应条件
phosphorus pentachloride in water
反应条件
trichlorophosphate in water
反应条件
1.1: nitric acid; sulfuric acid / water / 1 h / 80 °C 2.1: trichlorophosphate; quinoline / 5.5 h / Reflux 2.2: Cooling with ice View Scheme
参考文献
Chun, Kwangwoo; Park, Ji-Seon; Lee, Han-Chang; Kim, Young-Ha; Ye, In-Hea; Kim, Kang-Jeon; Ku, Il-Whea; Noh, Min-Young; Cho, Goang-Won; Kim, Heejaung; Kim, Seung Hyun; Kim, Jeongmin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3983 - 3987
反应条件
potassium carbonate in acetone
参考文献
Glenn JR., Robert Wayne; Katritzky, Alan Roy; Block, Eric; Shair, Matthew David; Ehlis, Thomas; Lupia, Joseph Anthony
Patent: US2002/12639 A1, 2002 ;
Title/Abstract Full Text Show Details
The Procter and Gamble Company
Patent: US6495125 B2, 2002 ;
反应条件
1.1: nitric acid; sulfuric acid / water / 1 h / 80 °C
2.1: trichlorophosphate; quinoline / 5.5 h / Reflux
2.2: Cooling with ice
3.1: thiourea / ethanol / 5.5 h / 50 °C
3.2: 1.5 h / 20 °C
3.3: Cooling with ice
4.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C
View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; IWAKOSHI, Mitsuhiko
Patent: WO2011/43404 A1, 2011 ;
反应条件
1.1: nitric acid; sulfuric acid / water / 1 h / 80 °C
2.1: trichlorophosphate; quinoline / 5.5 h / Reflux
2.2: Cooling with ice
3.1: thiourea / ethanol / 5.5 h / 50 °C
3.2: 1.5 h / 20 °C
3.3: Cooling with ice
View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED; IWAKOSHI, Mitsuhiko
Patent: WO2011/43404 A1, 2011 ;
反应条件
caesium carbonate in acetonitrile
T=65 - 70°C; 14 h;
参考文献
CADILA HEALTHCARE LIMITED; SHRIVASTAVA, Brijesh Kumar
Patent: WO2012/14221 A1, 2012 ;
Location in patent: Page/Page column 15-16 ;
WO 2012/014221 A1
反应条件
hydrogen; platinum(IV) oxide in acetic acid
P=2585.81 Torr; 9 h;
参考文献
LG LIFE SCIENCES, LTD.
Patent: WO2006/104356 A1, 2006 ;
Location in patent: Page/Page column 32 ;
WO 2006/104356 A1
