1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux 2: tetrabutylammomium bromide / toluene / 10 h / Reflux View Scheme

1.1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C View Scheme

1.1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C 6.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C View Scheme

1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C View Scheme

1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice View Scheme