4-羟基-6-苯乙基吡喃-2-酮合成路线 (共 4 条)
反应条件
1: 4-hydroxy-6-methyl-2H-pyran-2-one With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: benzyl chloride in tetrahydrofuran; hexane T=20°C; Further stages.;
参考文献
Zhang, Xuejun; McLaughlin, Michael; Munoz, R. Lizeth P.; Hsung, Richard P.; Wang, Jiashi; Swidorski, Jacob
Synthesis, 2007 , # 5 p. 749 - 753
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane; dichloromethane
参考文献
Pharmacia and Upjohn Company
Patent: US5852195 A1, 1998 ;
US 5852195 A
反应条件
hydrogenchloride 18 h; Ambient temperature;
参考文献
Tawata, Shinkichi; Taira, Shigehiko; Kobamoto, Naotada; Ishihara, Masanobu; Toyama, Seizen
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 10 p. 1643 - 1645
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, hexane, 0 deg C, 60 min; Yield given. Multistep reaction;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP1203770 A1, 2002 ;
Location in patent: Page 55 ;