1-(2-硝基苯基)吡咯合成路线 （共 14 条）
反应条件
1: With acetic acid 1 h; Heating / reflux; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Action Pharma A/S
Patent: WO2007/141343 A1, 2007 ;
Location in patent: Page/Page column 37 ;
WO 2007/141343 A1
反应条件
copper(l) iodide; caesium carbonate in dimethyl sulfoxide T=110°C; 24 h;
参考文献
Reddy, V. Prakash; Kumar, A. Vijay; Rao, K. Rama
Tetrahedron Letters, 2011 , vol. 52, # 7 p. 777 - 780
反应条件
potassium phosphate in dimethyl sulfoxide T=80°C; Ullmann-Goldberg Substitution; 2 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 55, # 4 p. 941 - 944
反应条件
sodium tetrahydroborate; sulfuric acid; water in tetrahydrofuran; methanol T=10 - 20°C; 1.5 h; Yields of byproduct given;
参考文献
Verardo, Giancarlo; Dolce, Anna; Toniutti, Nicoletta
Synthesis, 1999 , # 1 p. 74 - 79
反应条件
8-Hydroxyquinoline 1-oxide; caesium carbonate; copper(I) bromide in dimethyl sulfoxide T=110°C; Ullmann coupling; 20 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Yang, Kai; Qiu, Yatao; Li, Zheng; Wang, Zhaoyang; Jiang, Sheng
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3151 - 3159
反应条件
1: With trichlorophosphate in tetrachloromethane T=0 - 10°C; 1.25 h; Heating / reflux; 2: With water; sodium acetate in tetrachloromethane 0.25 h; Heating / reflux;
参考文献
Action Pharma A/S
Patent: WO2007/141343 A1, 2007 ;
Location in patent: Page/Page column 37 ;
WO 2007/141343 A1
反应条件
trichlorophosphate in N,N-dimethyl-formamide
参考文献
American Home Products Corporation
Patent: US5521173 A1, 1996 ;
US 5521173 A
反应条件
hydrogenchloride; iron in water 48 h; Reflux;
参考文献
De Fatima Pereira, Maria; Thiery, Valerie
Organic Letters, 2012 , vol. 14, # 18 p. 4754 - 4757,4
反应条件
bismuth(III) chloride; sodium tetrahydroborate in ethanol 2 h; Ambient temperature;
参考文献
Guillon, Jean; Dallemagne, Patrick; Pfeiffer, Bruno; Renard, Pierre; Manechez, Dominique; Kervran, Alain; Rault, Sylvain
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 4 p. 293 - 308
反应条件
acetic acid in ethanol; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6207693 B1, 2001 ;
