3-(4-溴-苯基)-异噁唑-5-羧酸乙酯合成路线 (共 12 条)
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Reflux;
参考文献
Andrzejak, Virginie; Muccioli, Giulio G.; Body-Malapel, Mathilde; El Bakali, Jamal; Djouina, Madjid; Renault, Nicolas; Chavatte, Philippe; Desreumaux, Pierre; Lambert, Didier M.; Millet, Regis
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3777 - 3786
反应条件
1: 4-bromophenylcarbonyloxymethyl-Wang resin; Tebbe reagent in tetrahydrofuran T=25°C; Tebbe olefination; 16 h; 2: ethyl chlorooximidoacetate With triethylamine in tetrahydrofuran 3: With trifluoroacetic acid in dichloromethane T=25°C; Further stages.;
参考文献
Barrett, Anthony G. M.; Procopiou, Panayiotis A.; Voigtmann, Ulrike
Organic Letters, 2001 , vol. 3, # 20 p. 3165 - 3168
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Reflux;
参考文献
US2010/63041 A1, ;
Page/Page column 33 ;
反应条件
hydroxylamine hydrochloride in ethanol 1 h; Heating;
参考文献
Synthesis, , # 15 p. 2325 - 2330
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Reflux;
参考文献
Letters in Organic Chemistry, , vol. 7, # 1 p. 32 - 38
反应条件
hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine in ethanol 2 h; Reflux;
参考文献
Letters in Organic Chemistry, , vol. 7, # 1 p. 32 - 38
反应条件
1: sodium ethanolate / tetrahydrofuran; ethanol 2: hydroxylamine hydrochloride / ethanol / 85 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 892 - 898
反应条件
hydroxylamine hydrochloride; toluene-4-sulfonic acid in toluene 2 h; RefluxDean-Stark apparatus;
参考文献
Letters in Organic Chemistry, , vol. 7, # 1 p. 32 - 38
反应条件
hydroxylamine hydrochloride; toluene-4-sulfonic acid in toluene 2 h; RefluxDean-Stark apparatus;
参考文献
Letters in Organic Chemistry, , vol. 7, # 1 p. 32 - 38
反应条件
1: With sodium hydroxide in ethanol T=20°C; 24 h; 2: With hydrogenchloride in water pH=2;
参考文献
Andrzejak, Virginie; Muccioli, Giulio G.; Body-Malapel, Mathilde; El Bakali, Jamal; Djouina, Madjid; Renault, Nicolas; Chavatte, Philippe; Desreumaux, Pierre; Lambert, Didier M.; Millet, Regis
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3777 - 3786