(2-氯-6-氟苯基)-对甲苯胺合成路线 （共 11 条）
反应条件
tri-tert-butyl phosphine; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) in toluene T=110°C; Buchwald-Hartwig coupling; 14 h;
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) in toluene T=110°C; Buchwald-Hartwig coupling;
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
hydrogenchloride; sodium chloride; tris-(dibenzylideneacetone)dipalladium(0) in water; toluene
参考文献
Novartis AG
Patent: US6291523 B1, 2001 ;
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=60 - 62°C; 1.5 h;
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
sodium t-butanolate; [(t-Bu)3PH]BF4; palladium diacetate in toluene T=160°C; 3 h; microwave irradiation;
参考文献
Bedford, Robin B.; Betham, Michael; Charmant, Jonathan P.H.; Weeks, Amanda L.
Tetrahedron, 2008 , vol. 64, # 26 p. 6038 - 6050
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C View Scheme
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C View Scheme
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 - 4 °C 1.2: 91 percent / dimethylformamide / 20 h / 50 - 55 °C 2.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 2.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 3.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 4.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C View Scheme
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
1: propan-2-ol / Heating 2: MeONa / methanol / 2 h / 85 °C View Scheme
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
反应条件
1.1: HCl gas / ethyl acetate / 2.5 h / -5 - 0 °C 1.2: H2O / ethyl acetate / 36 h / 20 - 25 °C 2.1: 80 percent / H2SO4; EtOH; H2O / H2O / 4 h / 66 - 70 °C 3.1: 83 percent / Red-Al / toluene / 1.5 h / 60 - 62 °C View Scheme
参考文献
Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David
Tetrahedron, 2004 , vol. 60, # 50 p. 11571 - 11586
