1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes
T=-78°C; 1 h;
2: 2-chloro-6-methoxypyrazine in tetrahydrofuran; hexanes
T=-78°C; 1 h;
3: carbon dioxide With hydrogenchloride
more than 3 stages;
参考文献
SCIOS, INC.
Patent: WO2006/112828 A1, 2006 ;
Location in patent: Page/Page column 96 ;
WO 2006/112828 A1