N-氨基-1H-苯并吡唑合成路线 （共 17 条）
反应条件
sodium hydroxide; hydroxylamine-o-sulphonic acid in ethanol; water; ethyl acetate
参考文献
Dae Woong Pharmaceutical Co., Ltd.
Patent: US5336673 A1, 1994 ;
反应条件
potassium hydroxide; hydroxylamine-o-sulphonic acid 1.) DMF, 2.) DMF, RT, 1 h; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 2 p. 570 - 581
参考文献
Cerecetto; Mester; Onetto; Seoane; Gonzalez; Zinola
Farmaco, 1992 , vol. 47, # 9 p. 1207 - 1213
反应条件
oxygen; nitrogen(II) oxide in acetonitrile T=20°C; Deamination; 0.0833333 h;
参考文献
Itoh, Takashi; Miyazaki, Michiko; Maeta, Hiromi; Matsuya, Yuji; Nagata, Kazuhiro; Ohsawa, Akio
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 1983 - 1989
反应条件
1: Pb(OCOCH3)4 2: ZnBr2 / CHCl3 / 2 h / 90 - 100 °C / other 1,2,3-benzotriazine, other enamines of karbonyl compounds View Scheme
参考文献
Koyama, Junko; Toyokuni, Izumi; Tagahara, Kiyoshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 332 - 334
反应条件
1: Pb(OCOCH3)4 2: 1.) pyrrolidine, p-TsOH, 2.) ZnBr2 / 1.) benzene, 10 h, 2.) chloroform, 90 deg C-100 deg C, 10 h View Scheme
参考文献
Koyama, Junko; Toyokuni, Izumi; Tagahara, Kiyoshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 332 - 334
反应条件
1: Pb(OCOCH3)4
2: 1.) pyrrolidine, p-TsOH, 2.) ZnBr2 / 1.) benzene, 10 h, 2.) chloroform, 90 deg C-100 deg C, 10 h
View Scheme
参考文献
Koyama, Junko; Toyokuni, Izumi; Tagahara, Kiyoshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 332 - 334
反应条件
1: Pb(OCOCH3)4
2: ZnBr2 / CHCl3 / 2 h / 90 - 100 °C
View Scheme
参考文献
Koyama, Junko; Toyokuni, Izumi; Tagahara, Kiyoshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 332 - 334
反应条件
1: Pb(OCOCH3)4
2: ZnBr2 / CHCl3 / 2 h / 90 - 100 °C
View Scheme
参考文献
Koyama, Junko; Toyokuni, Izumi; Tagahara, Kiyoshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 332 - 334
