2-氯-8-甲基喹啉-3-甲醇合成路线 （共 5 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=20°C; 2 h; 2: With sodium hydrogencarbonate in water
参考文献
EXELIXIS, INC.; LEAHY, James, William
Patent: WO2012/37204 A1, 2012 ;
Location in patent: Page/Page column 72; 73 ;
WO 2012/037204 A1
反应条件
1: 80 - 90 °C 2: sodium tetrahydroborate; water / 0.02 h / 20 °C View Scheme
参考文献
Roopan, Selvaraj Mohana; Nawaz Khan, Fazlur Rahman
Chemical Papers, 2010 , vol. 64, # 6 p. 812 - 817
反应条件
thionyl chloride in chloroform
T=20°C; 3 h;
参考文献
EXELIXIS, INC.; LEAHY, James, William
Patent: WO2012/37204 A1, 2012 ;
Location in patent: Page/Page column 72; 73 ;
WO 2012/037204 A1
反应条件
1: thionyl chloride / benzene / Reflux
2: triethylamine / ethanol / Reflux
View Scheme
参考文献
Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675
反应条件
1: thionyl chloride / benzene / Reflux
2: triethylamine / ethanol / Reflux
View Scheme
参考文献
Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675
