3,5-二氯-4-羟基苯甲酸合成路线 （共 36 条）
反应条件
potassium carbonate in acetone 16 h; Heating;
参考文献
Vaswani, Rishi G.; Chamberlin, A. Richard
Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1661 - 1681
反应条件
potassium carbonate in N,N-dimethyl-formamide Methylation;
参考文献
Roussi, Georges; Gonzalez Zamora, Eduardo; Carbonnelle, Annie-Claude; Beugelmans, Rene
Heterocycles, 1999 , vol. 51, # 9 p. 2041 - 2063
反应条件
borane-THF in tetrahydrofuran
T=0 - 20°C; 13.25 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/21401 A2, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/021401 A2
反应条件
2: K2CO3; butanone
View Scheme
参考文献
Tarbell; Wilson
Journal of the American Chemical Society, 1942 , vol. 64, p. 1066,1069
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 24 h;
2: With potassium hydroxide in methanol
1 h; Reflux;
3: With hydrogenchloride in methanol; water
pH=2 - 3;
参考文献
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; WAYNE STATE UNIVERSITY; HONG KONG POLYTECHNIC UNIVERSITY; CHAN, Tak-Hang; PAMU, Sreedhar; DOU, Qing Ping; CHEN, Di
Patent: WO2012/171114 A1, 2012 ;
Location in patent: Page/Page column 66; 67 ;
WO 2012/171114 A1
反应条件
1: With potassium hydroxide in ethanol
24 h;
2: With hydrogenchloride in ethanol; water
参考文献
Lindner, Wolfgang; Lammerhofer, Michael
Patent: US7064234 B2, 2006 ;
Location in patent: Page/Page column 22 ;
