3-(乙氧基羰基)-1,4-二甲基-1H-吡咯-2-乙酸乙酯合成路线 （共 16 条）
反应条件
aluminium trichloride in anhydrous dichloroethane; 1,2-dichloro-ethane
参考文献
Cell Pathways, Inc.; University of Arizona
Patent: US5721347 A1, 1998 ;
反应条件
aluminium trichloride in anhydrous dichloroethane; 1,2-dichloro-ethane
参考文献
Cell Pathways Inc
Patent: US5939417 A1, 1999 ;
反应条件
potassium carbonate in ethanol; water
16 h; Heating;
参考文献
Stahly, G. P.; Marlett, E. M.; Nelson, G. E.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4423 - 4426
反应条件
sulfuric acid in ethanol
T=60°C; var. reaction times; Product distribution;
参考文献
Stahly, G. P.; Marlett, E. M.; Nelson, G. E.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4423 - 4426
反应条件
1: 1) HCl, 2) aq. ammonia / 1) CHCl3, -10 deg C, 2) CHCl3, 70 deg C, 90 min, pH = 4.0
2: 20percent aq. NaOH / 2 h / Heating
3: 91 percent / TFA / 2 h / Heating
View Scheme
参考文献
Chang; Biftu; Boulton; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 363 - 369
反应条件
1: 1) HCl, 2) aq. ammonia
2: OH (1-)
3: BIO-Rad 50Wx8 cationic resin
4: pyrolysis
5: OH (1-)
View Scheme
参考文献
Chang; Biftu; Boulton; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 363 - 369
