3-羧基-1,4-二甲基-吡咯-2-乙酸合成路线 （共 9 条）
反应条件
sodium hydroxide in water T=100°C; 3 h;
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
hydrogenchloride in water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4363918 A1, 1982 ;
反应条件
sodium hydroxide in 1,4-dioxane T=90°C; 16 h;
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1: water / 1 h / 15 - 40 °C 2: sodium hydroxide / water / 3 h / 100 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., , vol. 126, # 10 p. 2666 - 2670,5
反应条件
sulfuric acid in ethanol; water T=75 - 80°C; 1.25 h;
参考文献
Stahly, G. P.; Marlett, E. M.; Nelson, G. E.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4423 - 4426
反应条件
1: 6 percent Chromat. / 96percent sulfuric acid / ethanol; H2O / 1.25 h / 75 - 80 °C 2: 71 percent / 96percent sulfuric acid / ethanol; H2O / 1.25 h / 75 - 80 °C View Scheme
参考文献
Ethyl Corporation
Patent: US4451658 A1, 1984 ;
反应条件
sulfuric acid in ethanol; water T=75 - 80°C; 1.25 h;
参考文献
Stahly, G. P.; Marlett, E. M.; Nelson, G. E.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4423 - 4426
参考文献
Cell Pathways Inc
Patent: US5939417 A1, 1999 ;
