DBN in toluene T=115°C; Friedel-Crafts acylation; 4 h; Inert atmosphere; regioselective reaction;

hydrogenchloride; tin(IV) chloride in nitromethane

in methylene chloride-toluene

chlorosulfonic acid; sodium acetate in methanol; chloroform; water

hydrogenchloride in dichloromethane; water

1.1: dichloromethane / 1 h / -10 - 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / pH 10 / Inert atmosphere 1.3: 0.5 h / Inert atmosphere 2.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere 2.2: 20 °C / pH 2 / Inert atmosphere 3.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 4.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere View Scheme

1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 2: DBN / toluene / 4 h / 115 °C / Inert atmosphere View Scheme

1.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere 1.2: 20 °C / pH 2 / Inert atmosphere 2.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 3.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere View Scheme

暂无反应条件数据

1: (4-methyl-phenyl)-(morpholin-4-yl)methanone With trichlorophosphate T=10 - 30°C; 2: 1-methylpyrrole-2-acetic acid methyl ester Product distribution / selectivity;