4-(5-氨基-1H-吡唑-3-基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
methanesulfonic acid; hydrazine hydrate in ethanol T=20°C; 1 h; Reflux;
参考文献
Hou, Zengye; Nakanishi, Isao; Kinoshita, Takayoshi; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Suzuki, Yamato; Nakamura, Shinya; Kure, Tatsuhide; Ohno, Hiroaki; Murata, Katsumi; Kitaura, Kazuo; Hirasawa, Akira; Tsujimoto, Gozoh; Oishi, Shinya; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2899 - 2903
反应条件
1: N-bromosuccinmide; p-toluenesulfonic acid monohydrate / acetonitrile / 2 h / 85 °C 2: ethanol; water / 1 h / 0 - 20 °C 3: methanesulfonic acid; hydrazine hydrate / ethanol / 1 h / 20 °C / Reflux View Scheme
参考文献
Hou, Zengye; Nakanishi, Isao; Kinoshita, Takayoshi; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Suzuki, Yamato; Nakamura, Shinya; Kure, Tatsuhide; Ohno, Hiroaki; Murata, Katsumi; Kitaura, Kazuo; Hirasawa, Akira; Tsujimoto, Gozoh; Oishi, Shinya; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2899 - 2903
反应条件
1: sulfuric acid / 3 h / 20 - 60 °C 2: N-bromosuccinmide; p-toluenesulfonic acid monohydrate / acetonitrile / 2 h / 85 °C 3: ethanol; water / 1 h / 0 - 20 °C 4: methanesulfonic acid; hydrazine hydrate / ethanol / 1 h / 20 °C / Reflux View Scheme
参考文献
Hou, Zengye; Nakanishi, Isao; Kinoshita, Takayoshi; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Suzuki, Yamato; Nakamura, Shinya; Kure, Tatsuhide; Ohno, Hiroaki; Murata, Katsumi; Kitaura, Kazuo; Hirasawa, Akira; Tsujimoto, Gozoh; Oishi, Shinya; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2899 - 2903
反应条件
1: ethanol; water / 1 h / 0 - 20 °C 2: methanesulfonic acid; hydrazine hydrate / ethanol / 1 h / 20 °C / Reflux View Scheme
参考文献
Hou, Zengye; Nakanishi, Isao; Kinoshita, Takayoshi; Takei, Yoshinori; Yasue, Misato; Misu, Ryosuke; Suzuki, Yamato; Nakamura, Shinya; Kure, Tatsuhide; Ohno, Hiroaki; Murata, Katsumi; Kitaura, Kazuo; Hirasawa, Akira; Tsujimoto, Gozoh; Oishi, Shinya; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2899 - 2903
