(R)-(+)-1-苯乙基异氰酸酯合成路线 （共 8 条）
反应条件
1: phosgene With n-butyl isocyanante in chlorobenzene T=20°C; 1 h; 2: (R)-1-phenyl-ethyl-amine in chlorobenzene T=72 - 87°C; 5 h;
参考文献
BASF Aktiengesellschaft
Patent: US6683204 B1, 2004 ;
Location in patent: Page column 5-6 ;
反应条件
N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in dichloromethane T=0°C;
参考文献
Sigurdsson, Snorri Th.; Seeger, Bodo; Kutzke, Ursula; Eckstein, Fritz
Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3883 - 3884
反应条件
1: With carbonyl diimidazole in acetonitrile T=20°C; Lossen rearrangement; 0.5 h; Inert atmosphere; 2: in acetonitrile T=60°C; Lossen rearrangement; Inert atmosphere;
参考文献
Organic Letters, , vol. 11, # 24 p. 5622 - 5625
反应条件
in dichloromethane 0.0833333 h; Ambient temperature;
参考文献
Peerlings; Meijer
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 1021 - 1024
参考文献
Journal of the American Chemical Society, , vol. 63, p. 871
反应条件
sodium hydroxide in toluene 0.666667 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 53, # 7 p. 1441 - 1450
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane 0.166667 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 11 p. 2175 - 2189
反应条件
1: 34 percent / CHCl3 / 7 h / Heating 2: 2) KOH / 1) thermal decomposition; 2) H2O, EtOH, reflux, 40 h View Scheme
参考文献
Chrzanowska; Schonenberger; Brossi
Helvetica Chimica Acta, 1987 , vol. 70, # 7 p. 1721 - 1731
