4-氨基丁基-1-(2-嘧啶)-哌嗪合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=-10°C; Yield given;
参考文献
Mead Johnson and Company
Patent: US4423049 A1, 1983 ;
反应条件
potassium carbonate in hydrazine hydrate; N,N-dimethyl-formamide
参考文献
Neurogen Corporation
Patent: US6100255 A1, 2000 ;
US 6100255 A
参考文献
Sumitomo Chemical Company, Limited
Patent: US4598078 A1, 1986 ;
反应条件
in water; ethylenediamine; butan-1-ol
参考文献
Pierre Fabre Medicament
Patent: US6303603 B1, 2001 ;
反应条件
1: 25percent aq. NaOH / acetone / Ambient temperature 2: LiAlH4 / diethyl ether / -10 °C View Scheme
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
hydrazine hydrate Multistep reaction;
参考文献
He, Xiao Shu; Woodruff, Kristine; Brodbeck, Robbin
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2399 - 2402
反应条件
in toluene 10 h; Heating;
参考文献
Yevich, J. P.; Temple, D. L.; New, J. S.; Taylor, Duncan P.; Riblet, L. A.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 194 - 203
反应条件
in pyridine Heating;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
参考文献
Abou-Gharbia, Magid; Patel, Usha R.; Webb, Michael B.; Moyer, John A.; Andree, Terrance H.; Muth, Eric A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1382 - 1392
反应条件
in pyridine
Heating;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
