3-(N-苯二甲酰亚氨基)丙酸合成路线 （共 47 条）
反应条件
phosphorus; bromine Heating;
参考文献
Golubev, A. A.; Semenenko, M. N.; Mandrugin, A. A.; Fedoseev, V. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 12 p. 1367 - 1369
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 12 p. 1687 - 1689
反应条件
1: concd. H2SO4 2: 36 percent / Zn/Hg, concd. HCl / H2O / 5.5 h / 100 °C View Scheme
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
参考文献
Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc
European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391
反应条件
thionyl chloride
und Behandeln des Reaktionsprodukts in Benzol mit Diazomethan in Aether;
参考文献
Padwa; Hasegawa; Liu; Zhang
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7124 - 7133
反应条件
1: 3-(phthalimido)propionic acid With diphenyl phosphoryl azide; triethylamine in benzene
0.666667 h; Heating / reflux;
2: tert-butyl alcohol in benzene
Heating / reflux;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6344462 B1, 2002 ;
Location in patent: Page column 62 ;
US 6344462 B1
反应条件
1.1: magnesium ethoxide / tetrahydrofuran / 4 h
1.2: 76 percent / N,N'-carbonyldiimidazole / dimethylformamide / 5 h / 20 °C
2.1: 74 percent / ammonium acetate; glacial acetic acid / toluene / Heating
3.1: sodium / ethanol / 0.5 h / 20 °C
3.2: 64 percent / ethyl chloroformate / tetrahydrofuran / 12 h / Heating
4.1: 76 percent / manganese(IV) oxide / toluene / 8 h / Heating
5.1: 29 percent / aq. hydrochloride acid / 14 h / Heating
View Scheme
参考文献
Hussenether, Thomas; Troschuetz, Reinhard
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 857 - 865
反应条件
boron trifluoride diethyl etherate; mercury(II) diacetate; hydroquinone
T=40°C; 5 h;
参考文献
Komarova, L. I.; Pokrovskaya-Dukhnenko, E. M.; Zaiko, I. A.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2089 - 2092
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2327 - 2331
反应条件
silver nitrate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water; acetone
T=55°C; Inert atmosphere; chemoselective reaction;
参考文献
Yin, Feng; Wang, Zhentao; Li, Zhaodong; Li, Chaozhong
Journal of the American Chemical Society, 2012 , vol. 134, # 25 p. 10401 - 10404
参考文献
Chapman Jr.; Cocolas; Hall
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 243 - 246
反应条件
1: Zn–Hg amalgam / 4 h / Reflux
2: sulfuric acid; nitric acid / 6 h / -5 °C
View Scheme
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
