1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C 1.2: 15 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C 3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.75 h / -78 °C 3.2: 0.5 h / -78 °C 4.1: zinc(II) hydroxide / water; tert-butyl methyl ether / 1 h / Inert atmosphere 4.2: 24 h 5.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C 5.2: 1 h / 20 °C 6.1: potassium tert-butylate / tetrahydrofuran / 0.83 h / 0 - 20 °C 6.2: 3 h 7.1: Dess-Martin periodane / dichloromethane / 2 h 8.1: hydrogen / palladium 10 on activated carbon / dichloromethane / 15 h / 103.43 Torr 9.1: tert-butylamine / ethyl acetate / 20 °C 9.2: pH 5 View Scheme

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C 2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.75 h / -78 °C 2.2: 0.5 h / -78 °C 3.1: zinc(II) hydroxide / water; tert-butyl methyl ether / 1 h / Inert atmosphere 3.2: 24 h 4.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C 4.2: 1 h / 20 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.83 h / 0 - 20 °C 5.2: 3 h 6.1: Dess-Martin periodane / dichloromethane / 2 h 7.1: hydrogen / palladium 10 on activated carbon / dichloromethane / 15 h / 103.43 Torr 8.1: tert-butylamine / ethyl acetate / 20 °C 8.2: pH 5 View Scheme

1.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.75 h / -78 °C 1.2: 0.5 h / -78 °C 2.1: zinc(II) hydroxide / water; tert-butyl methyl ether / 1 h / Inert atmosphere 2.2: 24 h 3.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C 3.2: 1 h / 20 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.83 h / 0 - 20 °C 4.2: 3 h 5.1: Dess-Martin periodane / dichloromethane / 2 h 6.1: hydrogen / palladium 10 on activated carbon / dichloromethane / 15 h / 103.43 Torr 7.1: tert-butylamine / ethyl acetate / 20 °C 7.2: pH 5 View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 0.83 h / 0 - 20 °C 1.2: 3 h 2.1: Dess-Martin periodane / dichloromethane / 2 h 3.1: hydrogen / palladium 10 on activated carbon / dichloromethane / 15 h / 103.43 Torr 4.1: tert-butylamine / ethyl acetate / 20 °C 4.2: pH 5 View Scheme

1.1: Dess-Martin periodane / dichloromethane / 2 h 2.1: hydrogen / palladium 10 on activated carbon / dichloromethane / 15 h / 103.43 Torr 3.1: tert-butylamine / ethyl acetate / 20 °C 3.2: pH 5 View Scheme

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere 1.2: 0.5 h / 26 °C / |Inert atmosphere 1.3: 20 h / 25 - 45 °C 2.1: carbon / ethyl acetate / 2 h / 25 - 40 °C 2.2: 20 - 25 °C / 1034.32 - 1292.9 Torr / |Inert atmosphere 3.1: potassium carbonate / methanol / 17 h / 25 - 35 °C / |Inert atmosphere 4.1: pyridinium p-toluenesulfonate / dichloromethane / 0.17 h / 25 °C / |Inert atmosphere 4.2: 16 h / 25 °C 5.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / -15 - -10 °C / |Inert atmosphere 6.1: diisobutylaluminium hydride / toluene / 2 h / -65 - 70 °C 7.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere 7.2: 2 h / 0 - 5 °C 8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 19 - 25 °C / |Inert atmosphere 8.2: 18 h / 20 - 25 °C 9.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 2 h / 6 - 12 °C / |Inert atmosphere 10.1: hydrogenchloride / acetonitrile; water / 4 h / 13 - 20 °C 11.1: carbon / ethyl acetate / 2 h / 20 °C 11.2: 1.5 h / 17 - 25 °C / 2250.23 Torr View Scheme

1.1: potassium carbonate / methanol / 17 h / 25 - 35 °C / |Inert atmosphere 2.1: pyridinium p-toluenesulfonate / dichloromethane / 0.17 h / 25 °C / |Inert atmosphere 2.2: 16 h / 25 °C 3.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / -15 - -10 °C / |Inert atmosphere 4.1: diisobutylaluminium hydride / toluene / 2 h / -65 - 70 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere 5.2: 2 h / 0 - 5 °C 6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 19 - 25 °C / |Inert atmosphere 6.2: 18 h / 20 - 25 °C 7.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 2 h / 6 - 12 °C / |Inert atmosphere 8.1: hydrogenchloride / acetonitrile; water / 4 h / 13 - 20 °C 9.1: carbon / ethyl acetate / 2 h / 20 °C 9.2: 1.5 h / 17 - 25 °C / 2250.23 Torr View Scheme

1.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / -15 - -10 °C / |Inert atmosphere 2.1: diisobutylaluminium hydride / toluene / 2 h / -65 - 70 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere 3.2: 2 h / 0 - 5 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 19 - 25 °C / |Inert atmosphere 4.2: 18 h / 20 - 25 °C 5.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 2 h / 6 - 12 °C / |Inert atmosphere 6.1: hydrogenchloride / acetonitrile; water / 4 h / 13 - 20 °C 7.1: carbon / ethyl acetate / 2 h / 20 °C 7.2: 1.5 h / 17 - 25 °C / 2250.23 Torr View Scheme

1.1: diisobutylaluminium hydride / toluene / 2 h / -65 - 70 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere 2.2: 2 h / 0 - 5 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 19 - 25 °C / |Inert atmosphere 3.2: 18 h / 20 - 25 °C 4.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 2 h / 6 - 12 °C / |Inert atmosphere 5.1: hydrogenchloride / acetonitrile; water / 4 h / 13 - 20 °C 6.1: carbon / ethyl acetate / 2 h / 20 °C 6.2: 1.5 h / 17 - 25 °C / 2250.23 Torr View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere 1.2: 2 h / 0 - 5 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 19 - 25 °C / |Inert atmosphere 2.2: 18 h / 20 - 25 °C 3.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 2 h / 6 - 12 °C / |Inert atmosphere 4.1: hydrogenchloride / acetonitrile; water / 4 h / 13 - 20 °C 5.1: carbon / ethyl acetate / 2 h / 20 °C 5.2: 1.5 h / 17 - 25 °C / 2250.23 Torr View Scheme