2-(3-氧代-2-哌嗪基)乙酸乙酯合成路线 （共 4 条）
反应条件
in propan-1-ol T=55°C; 16 h;
参考文献
Gruenenthal GmbH
Patent: US2008/312231 A1, 2008 ;
Location in patent: Page/Page column 40 ;
US 20080312231 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 3.66667 h; Heating / reflux; 2: With water in tetrahydrofuran 0.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/61511 A1, 2005 ;
Location in patent: Page/Page column 11 ;
WO 2005/061511 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
3.66667 h; Heating / reflux;
2: With water in tetrahydrofuran
0.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/61510 A1, 2005 ;
Location in patent: Page/Page column 13 ;
WO 2005/061510 A1
反应条件
in ethanol
T=60°C; 14 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/24729 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/024729 A1
