N-α-邻苯二酰-L-谷氨酰胺合成路线 （共 7 条）
反应条件
1: in N,N-dimethyl-formamide T=90 - 95°C; 3 h; 2: With hydrogenchloride; water T=15°C; pH=1.2; 2 h;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2008/35378 A2, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With sodium carbonate in water 1 h; Inert atmosphere; 2: With hydrogenchloride in water 1 h;
参考文献
Muller, George W.; Konnecke, William E.; Smith, Alison M.; Khetani, Vikram D.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 139 - 140
反应条件
1,4-dioxane; diethyl ether; ammonia
参考文献
Journal of the Chemical Society, , p. 3315,3318
反应条件
human serum albumin in phosphate buffer T=37°C; pH=7.40; Kinetics; Further Variations:Catalystscatalyst, buffer concentration;
参考文献
Chemical Research in Toxicology, , vol. 11, # 12 p. 1521 - 1528
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole in tetrahydrofuran 16 h; RefluxInert atmosphere;
参考文献
Muller, George W.; Konnecke, William E.; Smith, Alison M.; Khetani, Vikram D.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 139 - 140
反应条件
1: 67 percent / Ac2O 2: hydrogen / Raney-Ni deactivated with 3percent Pb / H2O; acetic acid View Scheme
参考文献
Masumi, Fumio; Takeuchi, Hiroshi; Kondo, Shigeo; Suzuki, Kikuji; Yamada, Shun-ichi
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3831 - 3833
反应条件
1,1'-carbonyldiimidazole; 4-(N,N-dimethlyamino)pyridine in acetonitrile 5 - 6 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2008/35378 A2, 2008 ;
Location in patent: Page/Page column 6 ;
