(R)-N-甲基-1-[3,5-二(三氟甲基)苯基]乙胺合成路线 （共 11 条）
反应条件
hydrogen; 5-palladium/activated carbon in methanol T=60°C; P=3750.38 Torr; 17.5 h;
参考文献
CENTRAL GLASS COMPANY, LIMITED
Patent: WO2004/22521 A1, 2004 ;
Location in patent: Page 57-58 ;
反应条件
1: With hydrogen; acetic acid; 5-palladium/activated carbon in methanol T=60°C; P=3750.38 Torr; 16 h; 2: With sodium hydroxide; water pH=> 12;
参考文献
Central Glass Co., Ltd.
Patent: EP2036881 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium carbonate in ethanol; water; ethyl acetate T=20 - 25°C;
参考文献
WO2007/48642 A1, ;
Page/Page column 9 ;
反应条件
1: With hydrogenchloride; water in propan-1-ol T=95°C; 20 h; 2: With sodium hydroxide in dichloromethane; water T=20°C; pH=12;
参考文献
EP2363388 A1, ;
Page/Page column 8 ;
反应条件
C23H25N3O2; trichlorosilane in ethyl acetate T=0°C; 5 h; Overall yield = 93 percent; Overall yield = 5.06 g;
参考文献
WO2013/79942 A1, ;
Page/Page column 29; 30 ;
反应条件
in water; toluene T=50°C; P=1350.14 Torr; 48 h;
参考文献
WO2006/67395 A1, ;
Page/Page column 22-23 ;
反应条件
sodium hydroxide in ethyl acetate
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
Location in patent: Page/Page column 60; 61 ;
反应条件
1.1: titanium(IV) isopropylate / tetrahydrofuran / 20 °C / Inert atmosphere 2.1: hydrogen; iodine / di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; C34H28FeNOP / acetone / 24 h / 20 °C / 18751.9 Torr 3.1: hydrogenchloride; water / propan-1-ol / 20 h / 95 °C 3.2: 20 °C / pH 12 View Scheme
反应条件
1.1: hydrogen; iodine / di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; C34H28FeNOP / acetone / 24 h / 20 °C / 18751.9 Torr 2.1: hydrogenchloride; water / propan-1-ol / 20 h / 95 °C 2.2: 20 °C / pH 12 View Scheme
反应条件
sodium hydroxide; water Product distribution / selectivity;
参考文献
EP2036881 A1, ;
Page/Page column 17-18 ;
