2-氧代-1,2,3,4-四氢嘧啶-5-羧酸乙酯合成路线 （共 13 条）
反应条件
1.1: bromine; acetic acid / 15 h / 20 - 110 °C
1.2: 2 h / pH 4
2.1: trichlorophosphate / 2 h / 117 °C / Cooling with ice
3.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h
3.2: 1 h / pH 1.5 - 4
4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
5.1: ammonia / 1,4-dioxane / 0.75 h / 20 °C
View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
反应条件
1: bromine; acetic acid / 1.5 h / Reflux
2: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux
3: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C
View Scheme
参考文献
CURIS, INC.
Patent: WO2009/36016 A1, 2009 ;
反应条件
1.1: bromine; acetic acid / 1.5 h / Reflux
2.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux
2.2: Cooling with ice
3.1: N,N-dimethyl-formamide / 1.5 h / 20 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
