(2S,5S)-N-Boc-5-甲基吡咯烷-2-甲酸合成路线 （共 13 条）
反应条件
lithium hydroxide in ethanol T=20°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
sodium hydroxide in water; acetonitrile T=20°C; 1 h;
参考文献
Miyazaki, Masaki; Naito, Hiroyuki; Sugimoto, Yuuichi; Yoshida, Keisuke; Kawato, Haruko; Okayama, Tooru; Shimizu, Hironari; Miyazaki, Masaya; Kitagawa, Mayumi; Seki, Takahiko; Fukutake, Setsuko; Shiose, Yoshinobu; Aonuma, Masashi; Soga, Tsunehiko
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4319 - 4331
反应条件
1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 2: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 20 °C 3: aq. LiOH / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
1: CF3COOH / CH2Cl2 / 3 h / 20 °C 2: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 20 °C 4: aq. LiOH / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
1: tetrahydrofuran / -40 - -20 °C 2: CF3COOH / CH2Cl2 / 3 h / 20 °C 3: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 4: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 20 °C 5: aq. LiOH / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
1: CH2Cl2 / 20 °C 2: tetrahydrofuran / -40 - -20 °C 3: CF3COOH / CH2Cl2 / 3 h / 20 °C 4: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 5: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 20 °C 6: aq. LiOH / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
1: 4-(dimethylamino)pyridine; triethylamine / CH2Cl2 / 20 °C 2: aq. LiOH / ethanol / 4 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
反应条件
1.1: tetrahydrofuran / -40 - -20 °C / |Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane 3.1: palladium on activated charcoal; hydrogen / methanol / 3040.2 Torr 4.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane 5.1: lithium hydroxide hydrate / tetrahydrofuran 5.2: pH 4 View Scheme
反应条件
1.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane 2.1: lithium hydroxide hydrate / tetrahydrofuran 2.2: pH 4 View Scheme
反应条件
1: tetrahydrofuran; diethyl ether / 2 h / -78 - 20 °C / |Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr 4: sodium hydroxide / acetonitrile; water / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 14 p. 4319 - 4331
