5-[2-乙氧基-5-(4-乙基哌嗪-1-基磺酰基)吡啶-3-基]-3-乙基-2-(2-甲氧基乙基)-2,6-二氢-7H-吡唑并[4,3-d]嘧啶-7-酮合成路线 （共 13 条）
反应条件
1.1: triethylamine / dichloromethane / 1 h / 0 °C / Cooling with ice 2.1: ethanol / 18 h / Reflux 3.1: tetrakis(triphenylphosphine) palladium(0) / 18 h / 100 °C / 10343.2 Torr 4.1: sodium hydroxide / ethanol / 2 h / 20 - 25 °C 4.2: pH 5 5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h 6.1: potassium hexamethylsilazane / ethanol / 6 h / 130 °C / Sealed tube View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 498 - 509
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 1.5 h / 0 - 25 °C / Cooling with ice 1.2: 3 h / 125 °C 2.1: triethylamine / dichloromethane / 1 h / 0 °C / Cooling with ice 3.1: ethanol / 18 h / Reflux 4.1: tetrakis(triphenylphosphine) palladium(0) / 18 h / 100 °C / 10343.2 Torr 5.1: sodium hydroxide / ethanol / 2 h / 20 - 25 °C 5.2: pH 5 6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h 7.1: potassium hexamethylsilazane / ethanol / 6 h / 130 °C / Sealed tube View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 1 p. 498 - 509
反应条件
water in butanone Heating;
参考文献
Hajikarimian, Yousef; Yeo, Steve; Ryan, Robert W.; Levett, Philip; Stoneley, Christopher; Singh, Paul
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 1027 - 1031
