2-氨基-5-溴-3-(羟甲基)吡啶合成路线 （共 5 条）
反应条件
bromine in acetic acid T=20°C; Product distribution / selectivity;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 30-31 ;
WO 2011/061214 A1
反应条件
bromine in sodium carbonate; acetic acid
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux 1.2: 0 °C 2.1: bromine / acetic acid / 20 °C View Scheme
参考文献
WO2011/61214 A1, ;
WO 2011/061214 A1
反应条件
1.1: hydrogen bromide / water / Reflux 2.1: sodium methylate / methanol / 0.75 h / 20 °C 2.2: 20 °C View Scheme
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
WO 2011/061214 A1
反应条件
1.1: hydrogen bromide / water / Reflux 2.1: sodium methylate / methanol / 0.75 h / 20 °C 2.2: 20 °C 3.1: sodium hydroxide / methanol / 4 h / 20 °C / Reflux 3.2: 20 °C / Reflux View Scheme
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
WO 2011/061214 A1
