6-溴-2-氧代-2,3,4,8-四氢-1,8-萘啶-3-甲酸甲酯合成路线 （共 7 条）
反应条件
1: malonic acid dimethyl ester With sodium methylate in methanol T=20°C; 0.75 h; 2: 3-bromo-5-bromo-methyl-6-amino-pyridine in methanol T=20°C;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 31 ;
WO 2011/061214 A1
反应条件
sodium methylate in methanol
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1.1: bromine / acetic acid / 20 °C 2.1: hydrogen bromide / water / Reflux 3.1: sodium methylate / methanol / 0.75 h / 20 °C 3.2: 20 °C View Scheme
参考文献
WO2011/61214 A1, ;
WO 2011/061214 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux 1.2: 0 °C 2.1: bromine / acetic acid / 20 °C 3.1: hydrogen bromide / water / Reflux 4.1: sodium methylate / methanol / 0.75 h / 20 °C 4.2: 20 °C View Scheme
参考文献
WO2011/61214 A1, ;
WO 2011/061214 A1
反应条件
1.1: hydrogen bromide / water / Reflux 2.1: sodium methylate / methanol / 0.75 h / 20 °C 2.2: 20 °C View Scheme
参考文献
WO2011/61214 A1, ;
WO 2011/061214 A1
反应条件
1: hydrogen bromide / water / 16 h / |Reflux 2: sodium methylate / methanol / 16 h / 20 - 35 °C View Scheme
反应条件
sodium hydroxide in methanol; CHCl3/CH3OH
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
