1: 6-methoxy-1H-indole-2-carboxylic acid methyl ester With 4-(N,N-dimethlyamino)pyridine; sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; Inert atmosphere;

暂无反应条件数据

in hexane; ethyl acetate; N,N-dimethyl-formamide; methyl iodide

1.1: anhydrous xylene / 6.33 h / Reflux 2.1: 4-(N,N-dimethlyamino)pyridine; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere View Scheme

1.1: sodium methylate / methanol / -8 - 5 °C 2.1: anhydrous xylene / 6.33 h / Reflux 3.1: 4-(N,N-dimethlyamino)pyridine; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere View Scheme