1-苄氧基-4-(2-溴乙氧基)苯合成路线 （共 31 条）
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 55 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 96 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 80 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 85 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
hydrogen bromide in acetic acid
参考文献
Hoffmann-La Roche Inc.
Patent: US4387100 A1, 1983 ;
US 4387100 A
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 83 percent / 48percent HBr-acetic acid / 0.5 h / 25 °C
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
参考文献
Hoffmann-La Roche Inc.
Patent: US4387100 A1, 1983 ;
US 4387100 A
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 53 percent / 48percent HBr-acetic acid / 0.5 h / 25 °C
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 58 percent / 48percent HBr-acetic acid / 0.5 h / 25 °C
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 81 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
