3-(1H-咪唑-1-基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
1: methyl 3-amino-benzoate; ethane-1,2-dial in methanol; water T=20°C; 18 h; 2: formaldehyd With ammonium chloride in methanol; water 1 h; Reflux; 3: With hydrogenchloride in methanol; water 5 h; Reflux;
参考文献
Gilfillan, Lynne; Blair, Adele; Morris, Brian J.; Pratt, Judith A.; Schweiger, Lutz; Pimlott, Sally; Sutherland, Andrew
MedChemComm, 2013 , vol. 4, # 7 p. 1118 - 1123
反应条件
sulfuric acid Heating;
参考文献
Woltering, Thomas J.; Adam, Geo; Wichmann, Juergen; Goetschi, Erwin; Kew, James N.C.; Knoflach, Frederic; Mutel, Vincent; Gatti, Silvia
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1091 - 1095
反应条件
1.1: aq. methanol / 16 h / 20 °C 2.1: aq. NH4Cl / methanol / 1 h / Heating 2.2: aq. H3PO4 / methanol / Heating View Scheme
参考文献
Liu, Jingping; Chen, Jingbo; Zhao, Jingfeng; Zhao, Yuanhong; Li, Liang; Zhang, Hongbin
Synthesis, 2003 , # 17 p. 2661 - 2666
反应条件
1: With ammonium chloride in methanol 1 h; Heating; 2: With phosphoric acid in methanol Heating;
参考文献
Liu, Jingping; Chen, Jingbo; Zhao, Jingfeng; Zhao, Yuanhong; Li, Liang; Zhang, Hongbin
Synthesis, 2003 , # 17 p. 2661 - 2666
