1-Cbz-2-苯基-4-哌啶酮合成路线 （共 9 条）
反应条件
N,N-dimethyl (R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthyl phosphoramidite; bis(.eta.(2)-ethylene)(2,4,-pentanedionato)rhodium in 1,4-dioxane; water T=100°C; 2 h;
参考文献
Jagt, Richard B. C.; De Vries, Johannes G.; Feringa, Ben L.; Minnaard, Adriaan J.
Organic Letters, 2005 , vol. 7, # 12 p. 2433 - 2435
反应条件
ZnF2; [Pd(CH3CN)4](BF4)2; (R,R)-Me2-DuPhos in 1,4-dioxane; water T=50°C; 18 h;
参考文献
Gini, Francesca; Hessen, Bart; Feringa, Ben L.; Minnaard, Adriaan J.
Chemical Communications, 2007 , # 7 p. 710 - 712
反应条件
1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine; trimethylaluminum; copper(II) .beta.-naphthoate in diethyl ether; toluene; pentane T=-10°C; 14 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Mueller, Daniel; Alexakis, Alexandre
Organic Letters, 2012 , vol. 14, # 7 p. 1842 - 1845
反应条件
palladium (II) trifluoroacetate; (R,R)-Me2-DuPhos in tetrahydrofuran; water T=50°C; 22 h;
参考文献
Gini, Francesca; Hessen, Bart; Minnaard, Adriaan J.
Organic Letters, 2005 , vol. 7, # 23 p. 5309 - 5312
反应条件
tetrakis-(ethylene)-μ,μ'-dichlorodirhodium(I); (R,R)-1,2-bis(tert-butylsulfinyl)benzene in dichloromethane; water T=40°C; 5 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Zhang, Xiangyang; Chen, Jun; Han, Fuzhong; Cun, Linfeng; Liao, Jian
European Journal of Organic Chemistry, 2011 , # 8 p. 1443 - 1446
反应条件
[RhCl((R)-2,2'-bis(diphenylphosphine)-1,1'-binaphthyl)]2 in tetrahydrofuran T=20°C; 2 h;
参考文献
Shintani, Ryo; Tokunaga, Norihito; Doi, Hidenori; Hayashi, Tamio
Journal of the American Chemical Society, 2004 , vol. 126, # 20 p. 6240 - 6241
反应条件
C40H26F6N4O4Pd; potassium hydroxide in hexane; water T=60°C; 36 h; optical yield given as percent ee;
参考文献
Xu, Qin; Zhang, Rui; Zhang, Tao; Shi, Min
Journal of Organic Chemistry, 2010 , vol. 75, # 11 p. 3935 - 3937
反应条件
1: K(iPrO)3BH / tetrahydrofuran / 1 h / -15 °C 2: 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine; trimethylaluminum; copper(II) .beta.-naphthoate / diethyl ether; toluene; pentane / 14 h / -10 °C / Inert atmosphere View Scheme
参考文献
Mueller, Daniel; Alexakis, Alexandre
Organic Letters, 2012 , vol. 14, # 7 p. 1842 - 1845
反应条件
1: K(iPrO)3BH / tetrahydrofuran / 1 h / -15 °C 2: 1,1-bis(3,5-dimethylphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine; trimethylaluminum; copper(II) .beta.-naphthoate / diethyl ether; toluene; pentane / 14 h / -10 °C / Inert atmosphere View Scheme
参考文献
Mueller, Daniel; Alexakis, Alexandre
Organic Letters, 2012 , vol. 14, # 7 p. 1842 - 1845
