2-羟基-6-甲基苯甲酸甲酯合成路线 （共 16 条）
反应条件
titanium(IV) isopropylate; titanium tetrachloride in dichloromethane 1.) -40 deg C, 1 h, 2.) 0 deg C, 2 h;
参考文献
Chan, Tak-Hang; Brownbridge, Peter
Journal of the American Chemical Society, 1980 , vol. 102, # 10 p. 3534 - 3538
反应条件
potassium carbonate in methanol T=20°C;
参考文献
Citron, Christian A.; Rabe, Patrick; Dickschat, Jeroen S.
Journal of Natural Products, 2012 , vol. 75, # 10 p. 1765 - 1776
反应条件
in diethyl ether T=0°C; 2 h;
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
copper diacetate; manganese triacetate in acetic acid T=50°C; 1 h; Yield given. Title compound not separated from byproducts;
参考文献
Kates, Steven A.; Dombroski, Mark A.; Snider, Barry B.
Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2427 - 2436
反应条件
sulfuric acid 27 h; Heating;
参考文献
Hamada; Hara; Kawai; Kohno; Shioiri
Tetrahedron, 1991 , vol. 47, # 40 p. 8635 - 8652
参考文献
Tyman, John H. P.; Visani, Naina
Journal of Chemical Research, Miniprint, 1997 , # 1 p. 228 - 240
反应条件
1: 95 percent / aq. NaOH / ethanol / Heating 2: 90 percent / conc. sulfuric acid / 27 h / Heating View Scheme
参考文献
Hamada; Hara; Kawai; Kohno; Shioiri
Tetrahedron, 1991 , vol. 47, # 40 p. 8635 - 8652
反应条件
1.1: pyridine / 6 h / 0 °C 2.1: copper(l) iodide; methyllithium / tetrahydrofuran; diethyl ether / 1 h / -78 °C 2.2: 0.17 h / 20 °C 3.1: potassium carbonate / methanol / 20 °C View Scheme
参考文献
Citron, Christian A.; Rabe, Patrick; Dickschat, Jeroen S.
Journal of Natural Products, 2012 , vol. 75, # 10 p. 1765 - 1776
反应条件
1.1: copper(l) iodide; methyllithium / tetrahydrofuran; diethyl ether / 1 h / -78 °C 1.2: 0.17 h / 20 °C 2.1: potassium carbonate / methanol / 20 °C View Scheme
参考文献
Citron, Christian A.; Rabe, Patrick; Dickschat, Jeroen S.
Journal of Natural Products, 2012 , vol. 75, # 10 p. 1765 - 1776
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; thionyl chloride / ethylene glycol dimethyl ether / 3.5 h 2.1: pyridine / 6 h / 0 °C 3.1: copper(l) iodide; methyllithium / tetrahydrofuran; diethyl ether / 1 h / -78 °C 3.2: 0.17 h / 20 °C 4.1: potassium carbonate / methanol / 20 °C View Scheme
参考文献
Citron, Christian A.; Rabe, Patrick; Dickschat, Jeroen S.
Journal of Natural Products, 2012 , vol. 75, # 10 p. 1765 - 1776
