[2-(3-甲氧基苯基)乙基]甲胺合成路线 （共 12 条）
反应条件
in tetrahydrofuran; water T=20°C;
参考文献
UNIVERSITAeT DES SAARLANDES; HARTMANN, Rolf; MARCHAIS-OBERWINKLER, Sandrine; XU, Kuiying; WERTH, Ruth
Patent: WO2012/117097 A1, 2012 ;
Location in patent: Page/Page column 32 ;
WO 2012/117097 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=25°C;
参考文献
Xu, Wei; Zhang, Xiao-Ming; Mariano, Patrick S.
Journal of the American Chemical Society, 1991 , vol. 113, # 23 p. 8863 - 8878
反应条件
borane-THF in tetrahydrofuran Reduction; 18 h; Heating;
参考文献
Hashima, Hirofumi; Hayashi, Masahiko; Kamano, Yoshiaki; Sato, Nobuhiro
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1757 - 1766
反应条件
1: 98 percent / K2CO3 / tetrahydrofuran / 25 °C 2: 94 percent / LiAlH4 / tetrahydrofuran / 25 °C View Scheme
参考文献
Grewe et al.
Chemische Berichte, 1956 , vol. 89, p. 600,608
反应条件
1: 87 percent / LAH / tetrahydrofuran / 3 h / Heating 2: 5 percent / tributylhexadecylphosphonium bromide; 47 percent HBr / 1.5 h / Heating 3: 78 percent / ethanol / 3 h / Heating View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Sattler, Johann H.; Lienhart, Wolf-Dieter; Durchschein, Katharina; Winkler, Andreas; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 5 p. 1068 - 1071
反应条件
benzaldehyde anschliessend Behandeln des Reaktionsprodukts mit wss. Aethanol;
参考文献
Buck
Journal of the American Chemical Society, 1932 , vol. 54, p. 3661,3662
反应条件
1: 5 percent / tributylhexadecylphosphonium bromide; 47 percent HBr / 1.5 h / Heating 2: 78 percent / ethanol / 3 h / Heating View Scheme
参考文献
Hashima, Hirofumi; Hayashi, Masahiko; Kamano, Yoshiaki; Sato, Nobuhiro
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1757 - 1766
反应条件
1: 99 percent / ethanol; H2O / 3 h / 70 °C 2: 84 percent / BH3*THF / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Hashima, Hirofumi; Hayashi, Masahiko; Kamano, Yoshiaki; Sato, Nobuhiro
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1757 - 1766
反应条件
1.1: sodium hydroxide / dichloromethane; water / 16 h / 0 - 20 °C 2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 2.2: 0.5 h / 20 °C View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
benzene und Erwaermen des Reaktionsprodukts mit wss.Aethanol;
参考文献
Grewe et al.
Chemische Berichte, 1956 , vol. 89, p. 600,608
