2-(4-氯苯基)-4,4-二甲基-4,5-二氢-1,3-噁唑合成路线 （共 6 条）
反应条件
thionyl chloride T=20°C; 0.25 h;
参考文献
ASTRAZENECA AB
Patent: US2008/15237 A1, 2008 ;
Location in patent: Page/Page column 32 ;
US 20080015237 A1
反应条件
1: in chloroform T=80°C; P=206.859 - 517.148 Torr; 0.166667 h; microwave irradiation; 2: With thionyl chloride in chloroform T=80°C; 0.0333333 h; microwave irradiation;
参考文献
Katritzky, Alan R.; Cai, Chunming; Suzuki, Kazuyuki; Singh, Sandeep K.
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 811 - 814
反应条件
zinc(II) chloride in chlorobenzene 48 h; Inert atmosphereReflux;
参考文献
Bellamy, Estelle; Bayh, Omar; Hoarau, Christophe; Trecourt, Francois; Queguiner, Guy; Marsais, Francis
Chemical Communications, 2010 , vol. 46, # 37 p. 7043 - 7045
反应条件
1: 2-chloro-5-carboxybenzene With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine in dichloromethane 2: 2-amino-2-methyl-propan-1-ol in dichloromethane T=20°C; 6 h;
参考文献
Bandgar; Pandit
Tetrahedron Letters, 2003 , vol. 44, # 11 p. 2331 - 2333
反应条件
1.1: SOCl2 / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: CHCl3 / 0.17 h / 80 °C / 206.86 - 517.15 Torr / microwave irradiation 2.2: 90 percent / SOCl2 / CHCl3 / 0.03 h / 80 °C / microwave irradiation View Scheme
参考文献
AstraZeneca U.K. Limited
Patent: US6162808 A1, 2000 ;
US 6162808 A
反应条件
1: 55 percent / TFA, Et4NOTs / dimethylformamide / Ambient temperature; electrolysis, Pb-cathode, C-anode 2: 1N HCl / Heating View Scheme
参考文献
Shono; Kise; Nomura; Yamanami
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3577 - 3580
