3-(2-羟乙基)-2-恶唑烷酮合成路线 （共 15 条）
反应条件
pyridine; thionyl chloride in benzene T=30°C; 6 h;
参考文献
Vani; Chida; Srinivasan; Chandrasekharam; Singh
Synthetic Communications, 2001 , vol. 31, # 13 p. 2043 - 2046
反应条件
ytterbium(III) triflate T=180°C; 25 h; Reagent/catalyst;
参考文献
WO2014/39551 A1, ;
Paragraph 32 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 22°C; 3 h;
参考文献
Poindexter, Graham S.; Bruce, Marc A.; LeBoulluec, Karen L.; Monkovic, Ivo
Tetrahedron Letters, 1994 , vol. 35, # 40 p. 7331 - 7334
反应条件
1: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium bromide in water; acetone
T=0°C; 0.166667 h;
2: With trichloroisocyanuric acid in water; acetone
T=0 - 25°C; 12 h;
3: With hydrogenchloride in water
pH=~ 2;
参考文献
ANORMED INC.
Patent: WO2006/138350 A2, 2006 ;
Location in patent: Page/Page column 82 ;
WO 2006/138350 A2
反应条件
1: SOCl2 / CH2Cl2
2: KI, K2CO3 / toluene / Heating
3: H2 / Pd-C / methanol / 16 h / 50 °C
4: CHCl3 / 42 h / Heating
View Scheme
参考文献
Aschwanden; Kyburz; Schoenholzer
Helvetica Chimica Acta, 1976 , vol. 59, # 4 p. 1245 - 1252
