5-氯-4-羟基-1-甲基-2-氧代-1,2-二氢-3-喹啉羧酸合成路线 （共 12 条）
反应条件
hydrogenchloride; water; acetic acid in acetic anhydride T=20 - 85°C; 2 h; Inert atmosphereLarge scale;
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
hydrogenchloride in acetic acid T=60°C; 6 h;
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C 3: 91 percent / HCl / acetic acid / 6 h / 60 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C 4: 91 percent / HCl / acetic acid / 6 h / 60 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
1: NaH / dimethylformamide / 5 h / 85 °C 2: 91 percent / HCl / acetic acid / 6 h / 60 °C View Scheme
参考文献
Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
反应条件
in water; toluene T=100°C; 1 h;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
反应条件
water; trifluoroacetic acid in dimethyl sulfoxide; acetonitrile T=50°C; 2 h; Kinetics;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
反应条件
water; trifluoroacetic acid in dimethyl sulfoxide; acetonitrile T=50°C; 2 h; Kinetics; Further Variations:reaction partner content;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
反应条件
water; trifluoroacetic acid in dimethyl sulfoxide; acetonitrile T=50°C; 2 h; Kinetics; Further Variations:reaction partner content;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
反应条件
water; trifluoroacetic acid in dimethyl sulfoxide; acetonitrile T=50°C; 2 h; Kinetics; Further Variations:Reagents;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
