4-[(1-甲氧基-1-氧代-3-苯基丙烷-2-基)氨基]-4-氧代-3-(苯基甲氧羰基氨基)丁酸合成路线 （共 20 条）
反应条件
hydrogenchloride; anhydrous calcium acetate; triethylamine; thermolysin in 1,1-dimethylpropan-1-ol T=40°C; 72 h;
参考文献
Ye, Yun-Hua; Tian, Gui-Ling; Xing, Guo-Wen; Dai, Dong-Cheng; Chen, Gang; Li, Chong-Xi
Tetrahedron, 1998 , vol. 54, # 41 p. 12585 - 12596
反应条件
hydrogen; Rh-(R)-prophos in tetrahydrofuran T=23°C; P=760 Torr; Title compound not separated from byproducts;
参考文献
Fuganti, Claudio; Grasselli, Piero; Malpezzi, Luciana
Journal of Organic Chemistry, 1986 , vol. 51, # 7 p. 1126 - 1128
反应条件
in N-methyl-acetamide; water
参考文献
Toyo Soda Manufacturing Co. Ltd.; (Zaidanhojin) Sagami Chemical Research Center
Patent: US4165311 A1, 1979 ;
反应条件
nitric acid in dichloromethane T=0°C; nitrolysis; 2 h;
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
参考文献
Toyo Soda Manufacturing Co. Ltd.; (Zaidanhojin) Sagami Chemical Research Center
Patent: US4165311 A1, 1979 ;
反应条件
triethylsilane; palladium diacetate; triphenylphosphine in dichloromethane T=25°C; 5 h;
参考文献
Crich, David; Sasaki, Kaname; Rahaman, Md Yeajur; Bowers, Albert A.
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 3886 - 3893
反应条件
McIlvaine buffer; triethylamine; papain in ethyl acetate T=37°C; 72 h;
参考文献
Chen, S. T.; Wang, K. T.
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4589 - 4590
反应条件
McIlvaine buffer; triethylamine; papain in ethyl acetate T=37°C; 72 h;
参考文献
Chen, S. T.; Wang, K. T.
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4589 - 4590
反应条件
McIlvaine buffer; triethylamine; papain in ethyl acetate T=37°C; 72 h;
参考文献
Chen, S. T.; Wang, K. T.
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4589 - 4590
反应条件
potassium carbonate in water; acetic acid
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US5302743 A1, 1994 ;
