4-[(1-甲氧基-1-氧代-3-苯基丙烷-2-基)氨基]-4-氧代-3-(苯基甲氧羰基氨基)丁酸合成路线 （共 20 条）
反应条件
thermolysin-immobilized capsule membrane in chloroform T=45°C; 24 h;
参考文献
Okahata, Yoshio; Ijiro, Kuniharu
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 91 - 96
反应条件
hydrogenchloride; anhydrous calcium acetate; triethylamine; thermolysin in 1,1-dimethylpropan-1-ol T=40°C; 72 h;
参考文献
Ye, Yun-Hua; Tian, Gui-Ling; Xing, Guo-Wen; Dai, Dong-Cheng; Chen, Gang; Li, Chong-Xi
Tetrahedron, 1998 , vol. 54, # 41 p. 12585 - 12596
反应条件
thermolysin in water T=40°C; pH=6.8, 4 iterations in the nucleophile pool; Yield given;
参考文献
Petkov, D. D.; Stoineva, I. B.
Tetrahedron Letters, 1984 , vol. 25, # 34 p. 3751 - 3754
反应条件
protease from Clostridium thermohydrosulfuricum SV 12 in phosphate buffer; ethyl acetate T=40°C; pH=6.5;
参考文献
Yadav; Meshram; Prasad; Ganesh; Rao; Seenayya; Swamy; Reddy
Tetrahedron Asymmetry, 2001 , vol. 12, # 18 p. 2505 - 2508
反应条件
in acetonitrile 2 h; Ambient temperature;
参考文献
Ye, Lei; Ramstroem, Olof; Mosbach, Klaus
Analytical Chemistry, 1998 , vol. 70, # 14 p. 2789 - 2795
参考文献
Stoineva; Galunsky; Lozanov; Ivanov; Petkov
Tetrahedron, 1992 , vol. 48, # 6 p. 1115 - 1122
反应条件
in methanol T=21°C; 1 h; var. solvents time and temperatures; Product distribution;
参考文献
Yang, Chin-Ping; Su, Chein-Shyong
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5186 - 5191
反应条件
thermolysin T=25°C; Rate constant;
参考文献
Kawasaki, Takayoshi; Hoshino, Yu; Ishizu, Yukari; Mizushiro, Yu; Okahata, Yoshio
Chemistry Letters, 2005 , vol. 34, # 12 p. 1602 - 1603
反应条件
thermolysin T=25°C; Rate constant;
参考文献
Kawasaki, Takayoshi; Hoshino, Yu; Ishizu, Yukari; Mizushiro, Yu; Okahata, Yoshio
Chemistry Letters, 2005 , vol. 34, # 12 p. 1602 - 1603
反应条件
hydrogen; palladium on activated charcoal
参考文献
Zhou, Qingzhong; Huang, Zhen
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 1 p. 35 - 39
