2-[(4-甲氧基苯基)甲基]-8-(苯基甲基)-2,8-二氮杂螺[4.5]-1,3-癸二酮合成路线 （共 10 条）
反应条件
sodium acetate in acetic anhydride
参考文献
Scarborough, Robert M.; Mehrotra, Mukund; Pandey, Anjali; Smyth, Mark
Patent: US2003/55244 A1, 2003 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 2: With sodium acetate; acetic anhydride Heating;
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: Et3N / CH2Cl2 / 20 °C 2.1: ethanol; H2O / 18 h / Heating 3.1: conc. aq. HCl / 24 h / Heating 4.1: SOCl2 5.1: DIEA / acetonitrile / 20 °C 5.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: SOCl2 2.1: DIEA / acetonitrile / 20 °C 2.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1: BH3 / tetrahydrofuran / Heating 2: CAN / acetonitrile; H2O View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1: BH3 / tetrahydrofuran / Heating 2: CAN / acetonitrile; H2O 3: NaOH / dioxane View Scheme
参考文献
Mehrotra, Mukund M.; Heath, Julie A.; Rose, Jack W.; Smyth, Mark S.; Seroogy, Joseph; Volkots, Deborah L.; Ruhter, Gerd; Schotten, Theo; Alaimo, Lisa; Park, Gary; Pandey, Anjali; Scarborough, Robert M.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1103 - 1107
反应条件
1: BH3 / tetrahydrofuran / Heating 2: CAN / acetonitrile; H2O 3: NaOH / dioxane 4: H2 / Pd(OH)2/C / methanol / 5171.48 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
ammonium formate; palladium(II) hydroxide/carbon in ethanol
1 h; Heating / reflux;
参考文献
VIROCHEM PHARMA INC.
Patent: WO2007/65256 A1, 2007 ;
Location in patent: Page/Page column 52 ;
WO 2007/065256 A1
