8-苄基-2,8-二氮杂-螺[4,5]葵烷合成路线 （共 13 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1851 - 1856
反应条件
in water; acetonitrile
参考文献
Scarborough, Robert M.; Mehrotra, Mukund; Pandey, Anjali; Smyth, Mark
Patent: US2003/55244 A1, 2003 ;
反应条件
1.1: Et3N / CH2Cl2 / 20 °C 2.1: ethanol; H2O / 18 h / Heating 3.1: conc. aq. HCl / 24 h / Heating 4.1: SOCl2 5.1: DIEA / acetonitrile / 20 °C 5.2: NaOAc; Ac2O / Heating 6.1: BH3 / tetrahydrofuran / Heating 7.1: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: DIEA / acetonitrile / 20 °C 1.2: NaOAc; Ac2O / Heating 2.1: BH3 / tetrahydrofuran / Heating 3.1: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating 5.1: BH3 / tetrahydrofuran / Heating 6.1: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: SOCl2 2.1: DIEA / acetonitrile / 20 °C 2.2: NaOAc; Ac2O / Heating 3.1: BH3 / tetrahydrofuran / Heating 4.1: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating 4.1: BH3 / tetrahydrofuran / Heating 5.1: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1: BH3 / tetrahydrofuran / Heating 2: CAN / acetonitrile; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Xu, Yuelian; Caldwell, Timothy M.; Xie, Linghong; Chenard, Bertrand L.
Patent: US2008/247964 A1, 2008 ;
Location in patent: Page/Page column 35 ;
US 20080247964 A1
