8-苄基-2,8-二氮杂螺[4.5]癸烷-2-羧酸叔丁酯合成路线 （共 9 条）
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: DIEA / acetonitrile / 20 °C 1.2: NaOAc; Ac2O / Heating 2.1: BH3 / tetrahydrofuran / Heating 3.1: CAN / acetonitrile; H2O 4.1: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: Et3N / CH2Cl2 / 20 °C 2.1: ethanol; H2O / 18 h / Heating 3.1: conc. aq. HCl / 24 h / Heating 4.1: SOCl2 5.1: DIEA / acetonitrile / 20 °C 5.2: NaOAc; Ac2O / Heating 6.1: BH3 / tetrahydrofuran / Heating 7.1: CAN / acetonitrile; H2O 8.1: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: ethanol; H2O / 18 h / Heating 2.1: conc. aq. HCl / 24 h / Heating 3.1: SOCl2 4.1: DIEA / acetonitrile / 20 °C 4.2: NaOAc; Ac2O / Heating 5.1: BH3 / tetrahydrofuran / Heating 6.1: CAN / acetonitrile; H2O 7.1: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: SOCl2 2.1: DIEA / acetonitrile / 20 °C 2.2: NaOAc; Ac2O / Heating 3.1: BH3 / tetrahydrofuran / Heating 4.1: CAN / acetonitrile; H2O 5.1: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1.1: conc. aq. HCl / 24 h / Heating 2.1: SOCl2 3.1: DIEA / acetonitrile / 20 °C 3.2: NaOAc; Ac2O / Heating 4.1: BH3 / tetrahydrofuran / Heating 5.1: CAN / acetonitrile; H2O 6.1: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1: CAN / acetonitrile; H2O 2: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
1: BH3 / tetrahydrofuran / Heating 2: CAN / acetonitrile; H2O 3: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
反应条件
hydrogen; palladium dihydroxide in methanol P=5171.48 Torr;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 7 p. 1103 - 1107
