3-氨基-4-甲氧基吡啶合成路线 （共 12 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=2585.81 Torr; 6 h;
参考文献
Noritake, Yukinobu; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko
Inorganic Chemistry, 2013 , vol. 52, # 7 p. 3653 - 3662
反应条件
1: sulfuric acid; potassium nitrate / 0 °C / Inert atmosphere 2: methanol / 0 °C / Inert atmosphere 3: hydrogenchloride; iron / methanol; water / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 33 p. 6693 - 6704
反应条件
1: methanol / 0 °C / Inert atmosphere 2: hydrogenchloride; iron / methanol; water / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 33 p. 6693 - 6704
反应条件
1: nitric acid; sulfuric acid / 60 h / 70 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 5 h / 2068.65 Torr View Scheme
参考文献
WO2011/78984 A1, ;
WO 2011/078984 A1
反应条件
1: With hydrogenchloride; bromine in water T=20 - 55°C; 2: With ammonium hydroxide in water
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/78984 A1, 2011 ;
Location in patent: Page/Page column 62; 63 ;
WO 2011/078984 A1
反应条件
1: 80 percent / Br2, conc. HCl / 1 h View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
hydrogenchloride; water Diazotization;
参考文献
Reitmann
med. Ch. I. G., 1934 , vol. 2, p. 384,388
反应条件
1: With hydrogenchloride; dihydrogen peroxide in water T=0 - 20°C; 1 h; 2: With sodium hydrogencarbonate in water
参考文献
Brinkman, John A.; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Guertin, Kevin Richard; Marcopulos, Nicholas; Qi, Lida; Racha, Jagdish Kumar; Sarabu, Ramakanth; Tan, Jenny; Tilley, Jefferson Wright
Patent: US2007/270433 A1, 2007 ;
Location in patent: Page/Page column 47 ;
US 20070270433 A1
反应条件
1: 80 percent / Br2, conc. HCl / 1 h
3: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
4: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
5: 92 percent / Na / 0.25 h / Heating
6: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
1: 80 percent / Br2, conc. HCl / 1 h
3: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
4: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
5: 92 percent / Na / 0.25 h / Heating
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
