(2E,4E,6E,8E)-N-(2-羟基乙基)-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯酰胺合成路线 （共 4 条）
反应条件
1: triethylamine / acetonitrile; tetrahydrofuran / 0.33 h / -18 °C 2: acetonitrile; tetrahydrofuran; methanol / 2.33 h / -18 - 20 °C View Scheme
参考文献
Shealy; Frye; O'Dell; Thorpe; Kirk; Coburn Jr.; Sporn
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 6 p. 745 - 751
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=20°C; 24 h;
参考文献
Campos-Sandoval, Jose Angel; Redondo, Clara; Kinsella, Gemma K.; Pal, Akos; Jones, Geraint; Eyre, Gwen S.; Hirst, Simon C.; Findlay, John B. C.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4378 - 4387
反应条件
in benzene T=10 - 15°C; 0.75 h;
参考文献
Shealy; Frye; O'Dell; Thorpe; Kirk; Coburn Jr.; Sporn
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 6 p. 745 - 751
反应条件
in tetrahydrofuran; methanol; acetonitrile T=-18 - 20°C; 2.33333 h;
参考文献
Arsenov; Babitskaya; Vashkevich; Dad'kov; Kisel'; Kuz'mitskii; Strel'chenok
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 12 p. 657 - 660
